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Gender differences in stability of the instantaneous patterns of
body surface potentials during ventricular repolarisation.
Alexandru Dan Corlan,
Peter W. Macfarlane,
Luigi De Ambroggi,
Med Biol Eng Comput 41(5):536-542, 2003
ABSTRACT
Women have a higher risk of developing torsade de pointes under OT-prolonging
conditions. The electrophysiological differences between the sexes
that could account for this are largely unknown. The objective of
the work was to evaluate gender differences in repolarisation potentials
using a method that is independent of the specific electrical properties
of the thorax. 1410 normal recordings from the Glasgow 12-lead ECG
database and 52 normal ECG maps obtained separately in Milan were
analysed. The average difference between 1 and the correlation coefficient
of the instantaneous pattern at the peak of T with that at every
other instant is called the early repolarisation deviation index
(ERDI) for J-T peak and the late repolarisation deviation index (LRDI)
for T peak-T end. In standard ECG recordings the ERDI was 0.42 +/-
0.22 in females compared with 0.19 +/- 0.16 in males (p < 10(-6)).
The LRDI was higher in males under the age of 50. In body surface
maps the ERDI was 0.32 +/- 0.21 in females against 0.16 +/- 0.17
in males (p < 0.01) and the LRDI was non-significantly higher in
males. The pattern of instantaneous body surface potentials showed
gender differences during repolarisation with a method that is independent
of the electrical properties of the thorax.
[Medline]