A population
  model of age and gender specific cardiac troponin levels

Alexandru Dan Corlan

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A population model of age and gender specific cardiac troponin levels

Alexandru Dan Corlan,

:-, 2024

ABSTRACT

The range of the high-sensitivity cardiac troponin (HSCTN) values in the general population increases progressively with age More accurate normal limits for HSCTN, taking into account age and gender, are needed for the differential diagnosis and evaluation of the prognostic significance of increases that do not reach the vendor-supplied upper reference limits (URL). We performed an analysis of the high sensitivity cardiac troponin (HSCTN) of 21743 individuals, representative for the general US population, that were studied in the NHANES survey performed by the Center for Disease Control of the USA. The vendor supplied URL values are typically several times higher than the actual upper limit in subjects under 40 and correspond to the URL at ages between 51 and 84 for specific vendors and genders. For each HSCTN test variant, we considered each one year age group between 1 and 85 and either gender. The distribution of the logarithmed HSCTN for a given test variant and gender, in each subsample i, is relatively close to Gaussian Embedded Image. Two quadratic models, for the 1-15 and the 16-85 age ranges, were found to fit well with the µi, while the σi follow a linear model. We propose a standardised HSCTN based on such theoretical distributions, that are independent of testing kit, age and gender.

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