A.D. Corlan > RO

Alexandru Dan Corlan MD PhD

Publicaţii ştiinţifice

Modelare stohastica pentru predictia clinica

• Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. A simulation study. Corlan AD, Ross J. Theor Biol Med Model. 2011 Oct 12;8:37. [Medline]
• Kinetic laws, phase-phase expansions, renormalization group, and INR calibration M.O. Vlad, A.D. Corlan, F. Moran, R. Spang, P. Oefner, J. Ross Proceedings of the National Academy of Sciences of the USA published online before print April 6, 2009, doi:10.1073/pnas.0809855106 [publisher full text]
• Integration of clinical-epidemiological results. Open questions.
  A.D. Corlan.
  Informal workshop at the Romanian Academy: Chemical Kinetics, Biomathematics and Functional Genomics. Integration of Biological, Chemical and Physical Information, apr 15, 2009.
• Incremental parameter evaluation from incomplete data with application to the population pharmacology of anticoagulants.
  Vlad MO, Corlan AD, Moran F, Oefner P, Ross J.
  Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4627-32.
  [PubMed] [publisher full text]
• On anti-portfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology.
  Vlad MO, Corlan AD, Popa VT, Ross J.
  Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18398-403
  [PubMed] [publisher full text]

Electrocardiografie digitala

• Stability and sustained oscillations in a ventricular cardiomyocyte model. Amuzescu B, Georgescu A, Nistor G, Popescu M, Svab I, Flonta ML, Corlan AD. Interdiscip Sci. 2012 Mar;4(1):1-18. Epub 2012 Mar 6. [Medline]
• Stability and Self-Sustained Oscillations in a Ventricular Cardiomyocyte Model. Bogdan P. Amuzescu, Catalin Liviu Bichir, Adelina Georgescu, Gheorghe Nistor, Marin N. Popescu, Istvan Svab, Alexandru Dan Corlan, Maria-Luiza Flonta. Biophysical Journal, vol. 100, issue 3, p. 437a, 2011 DOI: 10.1016/j.bpj.2010.12.2577
• Intercellular conductance variability influences early repolarization potentials in a model of the myocardial tissue with stochastic architecture. Corlan, A.D., Amuzescu, B., Milicin, I., Iordachescu, V., Poenaru, E., Corlan, I., De Ambroggi, L. Advanced Topics in Electrical Engineering (ATEE), 2011 7th International Symposium on 12-14 May 2011 [IEEE Xplore]
• Body surface potential mapping. L. De Ambroggi, A.D. Corlan, in Comprehensive Electrocardiology Macfarlane, P.W., Oosterom, A. van Pahlm, O., Kligfield, P., Janse, M.. Camm, J. (Eds.) 2nd ed., Springer 2011, pg. 1375-1415
• Limit cycles by finite element method for a one - parameter dynamical system associated to the Luo - Rudy I model Cătăin Liviu Bichir, Adelina Georgescu, Bogdan Amuzescu, Gheorghe Nistor, Marin Popescu, Maria-Luiza Flonta, Alexandru Dan Corlan, Istvan Svab
  ROMAI J., 6, 2(2010), 27–39 [arXiv]
• Electrocardiographic patterns of early repolarization attributable to increased transient outward current in the subepicardial region. A simulation study. A D. Corlan, B. Amuzescu, I. Milicin, L. De Ambroggi. Congress of the European Society of Cardiology, 2009.
  [ Rezumat] [ Poster (PDF)]
• Feasibility of estimating maximum ion conductance parameters from the shape of the action potential. A simulation study. A.D. Corlan, B.P. Amuzescu, I. Milicin, G. Nistor, M.N. Popescu, A. Georgescu, M.O. Vlad Biophysical Journal, 2009, 96 (3): 664a 53-rd Annual Meeting of the Biophysical Society, Boston, 2009
• Stability and oscillations in a ventricular cardiomyocyte model studied using the tools of dynamic systems analysis and bifurcation theory M.N. Popescu, G. Nistor, A. Georgescu, A.D. Corlan, B.P. Amuzescu, C.I. Barbu, M.L. Flonta Biophysical Journal, 2009, 96 (3): 664a 53-rd Annual Meeting of the Biophysical Society, Boston, 2009
• Increased transient outward current in the subepicardial region can explain the slurring of the QRS. A simulation study. A.D. Corlan, B.P. Amuzescu, I. Milicin, L. De Ambroggi 36-th Congress of the International Society of Cardiology, Wroclaw, 24-27 Jun 2009 [ abstract] [ poster]
• Early repolarization (J) wave association with other repolarization features
  A.D. Corlan, B.M. Horacek, L. De Ambroggi.
  35-rd Congress Int. Soc. Electrocardiology, Sankt Petersburg 2008 [ Rezumat]
• Susceptibility for ventricular tachycardia and the correlation between depolarization and orthogonal components of repolarization.
  Corlan AD, Horacek M, De Ambroggi L.
  Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:139-41.
  [ PubMed] [publisher full text]
• Clinical use of body surface potential mapping in cardiac arrhythmias.
  De Ambroggi L, Corlan AD.
  Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:8-10.
  [PubMed] [publisher full text]
• Orthogonal Components Of The Body Surface Repolarization Map And The Depolarization Pattern
  A.D. Corlan, L. De Ambroggi.
  33-rd Congress Int. Soc. Electrocardiology, Koln 2006
• Prognostic value for ventricular tachycardia of indices of ventricular repolarization in patients with and without myocardial infarction
  A.D. Corlan, B.M. Horacek, L. De Ambroggi
  Folia cardiologica, 2005, vol 12. suppl D, 209--211.
• The effect of intrathoracic heart position on electrocardiogram autocorrelation maps.
  Corlan AD, Macleod RS, De Ambroggi L.
  J Electrocardiol. 2005 Apr;38(2):87-94.
• Normal variability of the QRS autocorrelation maps.
  A.D. Corlan, L. De Ambroggi.
  Advances in Electrocardiology 2004, World Scientific, 557--560.
• Prognostic value of heart rate variability after acute myocardial infarction.
  Balanescu S, Corlan AD, Dorobantu M, Gherasim L.
  Med Sci Monit. 2004 Jun 29;10(7):CR307-CR315.
• Prognostic value of T wave complexity. L. De Ambroggi, A.D. Corlan. Italian Heart Journal 2004, 5: 176S--178S
• Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarization.
  A.D. Corlan, P.W. Macfarlane, L. De Ambroggi.
  IEE Medical and Biological Engineering and Computing, 2003, 41: 536--542
• Low variability of autocorrelation maps with intrathoracic heart position.
  A.D. Corlan, R.S. Macleod, L. De Ambroggi.
  International Journal of Bioelectromagnetism, 2003, 5(1), 139--140
• Variability of Simulated ECG Autocorrelation Maps with Electrode Placement.
  A.D. Corlan, R. Corlan, L. De Ambroggi.
  International Journal of Bioelectromagnetism, 2002 4(2): 347--348
• New methods for the analysis of ventricular repolarization potentials.
  L. De Ambroggi, A.D. Corlan.
  J Electrocardiology, 2001, 34(4), p. 333
• Valoarea diagnostica a diagramelor sinoptice pentru aritmiile cardiace.
  A.D. Corlan.
  Teza de doctorat. 2001.
• Autocorrelation Maps---A New Method for the Analysis of Repolarization Potentials.
  A.D. Corlan, L. De Ambroggi.
  Electrocardiology '2001, Editora Atheneo, Sao Paolo, Brazil, pp. 35--39
• New quantitative methods of ventricular repolarization analysis in patients with left ventricular hypertrophy.
  A.D. Corlan, L. De Ambroggi.
  Italian Heart Journal, 2000; 1(8): 542--548
• Simulated effects of inhomogeneities of ventricular repolarization on the electrocardiogram.
  A.D. Corlan.
  Electrocardiology '2000, pag. 91--96, Roma 2001
• Computer simulation of the repolarization changes in arrhythmogenic right ventricular dysplasia.
  A.D. Corlan, L. De Ambroggi.
  Electrocardiology '99 Syktyvkar 1999, pp. 127--131
• Indices of vulnerability to arrhythmias in arrhythmogenic right ventricular dysplasia.
  L. De Ambroggi, A.D. Corlan.
  Electrocardiology '99, Syktyvkar, 1999, pp. 235--239
• Analysis of the Repolarization Potentials in Left Ventricular Hypertrophy.
  A.D. Corlan, C. Cerioti, N. Erba, E. Aime, L. De Ambroggi.
  Electrocardiology '98, World Scientific Publishing, 1998, pp. 389--395
• Analisi delle alterazioni dei potenziali di ripolarizzatione nell'ipertrofia ventricolare sinistra.
  A.D. Corlan, C Cerioti, N. Erba, G.L. Ruffin, L. De Ambroggi.
  Cardiologia, 43, suppl 3, 1998
• Computer simulation of in-vitro atrioventricular node pacing experiments with coverage of the whole parameter space.
  A.D. Corlan, M. Cinteza, M. Dorobantu, D. Vinereanu, I. Vasilescu, S. Balanescu, D. Iosifescu, D. Dimulescu, O. Ioachimescu, L. Gherasim.
  Eur. Heart J.; 1997; 18, Abstr. Suppl.
• Clarrhmos---a general purpose simulator for the sequence of depolarization of the human myocardium.
  A.D. Corlan, R. Corlan, S. Balanescu, I. Vasilescu, M. Cinteza, D. Vinereanu, L. Gherasim.
  Integrating Cardiology Information Systems, Mainz, 1996.
• The hypothesis of atrioventricular node reentry during atrial fibrillation supported by computer simulation.
  A.D. Corlan, S. Balanescu, M. Cinteza, I. Vasilescu, M. Dorobantu, D. Vinereanu, D. Iosifescu, D. Dimulescu, L. Gherasim.
  Eur. Heart J.; 1996; 17, Abstr. Suppl.
• Aspect on Poincare diagram supports the hypothesis of atrioventricular re-entry during atrial fibrillation.
  A.D. Corlan, S. Balanescu, M. Cinteza, I. Vasilescu, M. Dorobantu, D. Vinereanu, D. Dimulescu, L. Gherasim.
  Eur. Heart J.; 1995; 16, Abstr. Suppl.:275
• A simulator for clinical models of supraventricular arrhythmias.
  A.D. Corlan, R. Corlan, M. Cinteza, S. Balanescu, I. Vasilescu, D. Vinereanu, L. Gherasim.
  Eur. Heart J.; 1995; 16, Abstr. Suppl.:242
• Poincare diagram shows four patterns of R-R interval succession in chronic atrial fibrillation. A.D. Corlan, S. Balanescu, M. Cinteza, M. Dorobantu, D. Vinereanu, I. Vasilescu, L. Gherasim. Eur. Heart J.; 1994; 15, Abstr. Suppl.:496
• Efectul tratamentului digitalic asupra aspectului fibrilatiei atriale pe diagramele Poincare.
  S. Balanescu, A.D. Corlan, G. Cerin, M. Cinteza, M. Dorobantu, D. Vinereanu, I. Vasilescu, L. Gherasim.
  Rev. Rom. Cardiol.;1994;4, 2:164
• Valoarea cardiotahogramei pentru identificarea disfunctiei tranzitorii a nodului sinusal.
  A.D. Corlan, S. Balanescu, M. Cinteza, I. Vasilescu, M. Dorobantu, D. Dimulescu, D. Iosifescu, N. Florescu, L. Gherasim.
  Rev. Rom. Cardiol.; 1995;5, 2: 92
• Aspectul pe diagrama Poincare sustine ipoteza existentei reintrarii în nodul atrioventricular în fibrilatia atriala.
  A.D. Corlan, S. Balanescu, M. Cinteza, I. Vasilescu, M. Dorobantu, D. Vinereanu, D. Dimulescu, L. Gherasim.
  Rev. Rom. Cardiol.; 1995;5,2: 92
• Clarrhmos--Simulator pentru modele clinice ale aritmiilor supraventriculare.
  A.D. Corlan, R. Corlan, M. Cinteza, S. Balanescu, I. Vasilescu, M. Dorobantu, D. Dimulescu, D. Iosifescu, D. Vinereanu, N. Florescu, L. Gherasim.
  Rev. Rom. Cardiol.; 1995; 5, 2: 93
• Insuficienta cardiaca se asociaza cu patru tipuri specifice de variatie a intervalului RR pe cardiotahograma.
  I. Vasilescu, A.D. Corlan, S. Balanescu, M. Cinteza, M. Dorobantu, D. Dimulescu, D. Iosifescu, N. Florescu, L. Gherasim.
  Rev. Rom. Cardiol.;1995;5, 2: 157
• The influence of amiodarone and propaphenone on sinus node variability.
  L. Gherasim, A.D. Corlan, M. Cinteza, S. Balanescu, I. Vasilescu.
  Simpozionul International, Timisoara, 1995
• Diagrame sinoptice pentru variatia succesiunii R--R în fibrilatia atriala.
  L. Gherasim, A.D. Corlan, S. Balanescu, M. Cinteza, M. Dorobantu, I. Vasilescu, D. Iosifescu, D. Vinereanu, R. Bengulescu.
  Conferinta Nationala de Cardiologie, Timisoara, 1993.
• Gliksee --- sistem computerizat de înregistrare si prelucrare a semnalelor ECG. Diagrame sinoptice pentru studiul comportamentului de durata al aritmiilor.
  A.D. Corlan, D. Vinereanu, M. Dorobantu, M. Cinteza, D. Dimulescu, L. Gherasim.
  Conferinta Nationala de Cardiologie, Târgoviste, 1992.

Predictia efectului derivatilor cumarinici prin modelare numerica

• Interactiunea intre diuretice si medicatia anticoagulanta orala
  R.I. Mincu, M.E. Iancu, A.D. Corlan, O. Parvu
  Revista Romana de Cardiologie, vol XXIV, nr. 1, 2009 1-4
• Farmacologia populationala a anticoagulantelor orale
  A.D. Corlan
  A 10-a Conferinta a Societatii de Probabilitati si Statistica din Romania, 2007
• Warfarissimo. Modelarea raspunsului la tratamentul anticoagulant oral
  A.D. Corlan
  Seminariile BioMat, noiembrie 2006
• Reducerea complicatiilor hemoragice ale tratamentului anticoagulant oral prin aplicarea clinica a predictiilor unui model computerizat
  A.D. Corlan, O. Pîrvu, R. Benga, I. Corlan, M. Iancu, C. Constantinescu, M. Florescu, G. Bicescu, S. Magda, C. Udroiu, L. Musat, S. Dobre, D. Vinereanu, M. Cinteza, L. Gherasim
  Simpozionul Viasan 2006
• Regim de administrare a Acenocumarolului cu interval de timp fractional
  O. Pârvu, A.D. Corlan
  Revista de Medicina si Farmacie - Orvosi es Gyogyszereszeti Szemle 2006, 52: 209-212
• Îmbunatatirea acuratetei dispozitivelor portabile de determinare a INR, prin compensarea diferetelor sistematice fata de laboratoarele standard
  R. Benga, A.D. Corlan, O.Pârvu
  Revista de Medicina si Farmacie - Orvosi es Gyogyszereszeti Szemle 2006, 52: 215-225
• R. Benga, M. Iordache, A.D. Corlan Testarea eficientei simulatorului "Warfarissimo" în controlul anticoagularii orale Revista de Medicina si Farmacie - Orvosi es Gyogyszereszeti Szemle 2005, 51: 51-52
• Predictia raspunsului INR la tratamentul anticoagulant oral prin modelarea computerizata a farmacocineticii si farmacodinamicii derivatilor cumarinici
  A.D. Corlan, O. Pârvu, I. Corlan, C. Constantinescu
  Simpozionul Viasan, 2004, pag 68-69.
• Consecinte cantitative ale modelului farmacologic al actiunii anticoagulantelor orale explorate prin simulare computerizata.
  A.D. Corlan, I. Corlan, C. Constantinescu.
  Terapeutica, Farmacologie si Toxicologie Clinica 2003, 7(3), 39--54

Altele

• On Markov chains with random time dependence
  A.D. Corlan, G. Zbaganu
  A 14-a Conferinta a Societatii de Probabilitati si Statistica din Romania
• Criterii de orientare a screening-ului în stenoza de artere renale
  R.O. Darabont, A.D. Corlan, N. Florescu, A. Tanase
  Revista Româna de Cardiologie, 2005, 20 (3), 203-210
• Relatia dintre maladia tromboembolica venoasa si neoplazia nou depistata.
  R.O. Darabont, A.D. Corlan
  Medicina Interna, 2004, 1(2), 63-68.